Nimasulide & Paracetamol Tablets

Product Description

A tablet combining Nimesulide and Paracetamol is a fixed-dose combination (FDC) medication that was previously very common in India for pain and fever relief. However, it's crucial to understand its current regulatory status and the concerns associated with it.

What are Nimesulide and Paracetamol?

1. Nimesulide:

   • Class: It is a Non-Steroidal Anti-inflammatory Drug (NSAID).
   • Mechanism of Action: Nimesulide primarily works by inhibiting the enzyme cyclooxygenase-2 (COX-2), which is involved in the production of prostaglandins. Prostaglandins are chemical messengers that cause pain, inflammation, and fever. By inhibiting their production, Nimesulide reduces these symptoms.
   • Concerns: Nimesulide has been associated with a risk of liver damage (hepatotoxicity), especially with prolonged use or in susceptible individuals. Due to these concerns, its use has been restricted or banned in many countries,